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Urinary acidification and distal renal tubular acidosis
Robert J Unwin1, David G Shirley, Giovambattista Capasso
1Centre for Nephrology, Department of Physiology, Royal Free and University College Medical School, London, UK. robert.unwin@ucl.ac.uk
Journal of Nephrology
|May 25, 2002
Abstract:
Historically, renal tubular acidosis (RTA) has been classified on a clinical basis, without any reference to the underlying disorder. Here we review the normal mechanisms of renal acidification and we identify disorders of specific transporters (genetic, disease-related or drug-induced) that lead to the main categories of distal RTA. We also describe the approach to diagnosis and the current treatment of distal RTA.