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Updated: Oct 1, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
5'-substituted-6-carboxylic-2,2'-bipyridine acid: a pivotal architecton for building preorganized ligands
Loïc J Charbonnière1, Nicolas Weibel, Raymond F Ziessel
1Laboratoire de Chimie Moléculaire, Associé au CNRS UMR-7008, Ecole de Chimie, Polymères et Matériaux de Strasbourg (ECPM), 25 rue Becquerel, 67087 Strasbourg Cedex 02, France.
Abstract:
A set of ligands bearing 6-bromo-2,2'-bipyridine pendant arms attached in the 5'-position are described. Transformation of the bromo to an ester was performed by a carboethoxylation reaction promoted by low-valent Pd(0), while saponification followed by acidification gave the acids. The introduction of an appended function 3-nitrobenzyl, benzamidomethyl, and tert-butylacetyl opens the way to further functionalize these scaffolds for potential labeling of biological material. The synthetic protocols represent a valuable approach to the rational design of ligands bearing oxophilic and anionic sidearms.
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