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Identification of two new HLA-A alleles, A*2419 and A*3011, by sequence-based typing
Christina E M Voorter1, E M van den Berg-Loonen
1Tissue Typing Laboratory, University Hospital Maastricht, Maastricht, The Netherlands.
Tissue Antigens
|May 25, 2002
Abstract:
In this report, we describe two new HLA-A alleles, A*2419 and A* 3011, that were initially recognized by an aberrant serological pattern. Sequence-based typing revealed sequence differences with other known HLA-A alleles. Allele A*2419 showed 4 nucleotide differences with A*2404, resulting in 4 amino acid differences at codons 70, 76, 77 and 90. Compared with other A*24 alleles, A*2419 lacks the Bw4 motif, as do A*2404 and A*2428. The A*3011 allele showed 2 mismatches with A*3001, resulting in one amino acid difference at codon 80.