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Related Experiment Videos

Were vertebrates octoploid?

Rebecca F Furlong1, Peter W H Holland

  • 1School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading RG6 6AJ, UK.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|May 25, 2002
PubMed
Summary
This summary is machine-generated.

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Gene and genome duplication are key to organismal complexity. Evidence supports two rounds of whole genome doubling in early vertebrate evolution, potentially via sequential autotetraploidy.

Area of Science:

  • Evolutionary Biology
  • Genomics
  • Molecular Phylogenetics

Background:

  • The role of gene and genome duplication in the evolution of organismal complexity is a long-standing hypothesis.
  • Ohno's 'two tetraploidies' hypothesis suggests two whole genome doublings in vertebrate evolution facilitated increased complexity.
  • Recent doubts have emerged regarding the direct evidence for early vertebrate tetraploidy.

Purpose of the Study:

  • To review and evaluate the evidence for and against tetraploidy in early vertebrate evolution.
  • To present new molecular phylogenetic data for amphioxus.
  • To reconcile conflicting observations with the genome duplication hypothesis.

Main Methods:

  • Review of existing evidence for and against early vertebrate tetraploidy.

Related Experiment Videos

  • Compilation and analysis of molecular phylogenetic data for amphioxus.
  • Re-evaluation of genomic observations in light of alternative duplication models.

    • Main Results:

    • The evidence supporting tetraploidy in early vertebrate evolution, based on genome and gene family analyses, is robust.
    • Observations previously cited against genome duplication are compatible with sequential autotetraploidy.
    • New molecular phylogenetic data for amphioxus are presented.

    Conclusions:

    • The hypothesis of two rounds of whole genome doubling in early vertebrate evolution is strongly supported.
    • The genome doubling likely occurred through two closely spaced rounds of autotetraploidy.
    • Early vertebrates may have undergone an autoautooctoploid phase in their genome evolution.