[Prevention of ischemic heart disease with hyperlipidemia]

Atherosclerotic vascular diseases are expected to remain the major cause of mortality and morbidity globally well. Preventive measures by lifestyle changes(diet, exercise) will play an important role in retarding the onset of these diseases. The 4S, CARE and LIPID study demonstrated the efficacy of a statin on cardiovascular morbidity and mortality and on total mortality. The cardioprotective effect of statin is partially due to the cholesterol independent effect. Fibrate also decrease the mortality of patients with ischemic heart disease by improving the fiblolytic state. The association of a statin and a fibrate is reserved to specialized centers, however we should not forget the usefulness of diet.