Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inheritance of Chromatin Structures

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...

Euchromatin

Euchromatin

The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions take up more dye, appearing darker, while the less-compact areas take up less dye and appear lighter. Based on the compaction level, chromatins are classified into two primary forms – euchromatin and heterochromatin.
Euchromatin is the less dense region of the chromatin and stains lighter. Euchromatin contains histone H3 extensively...

$X-ray Diffraction of Biological Samples$ 01:10

X-ray Diffraction of Biological Samples

X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are scattered by the electron clouds around the sample atoms. The X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal crystal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Analysis of effective substances in Shuangshen Fuzheng San and its mechanism study on human lung adenocarcinoma A549 cells].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026

Same author

Evolution of alkaline hydrogen oxidation reaction mechanisms and design of Pt-based catalysts from adsorption descriptors to interfacial microenvironment engineering.

Chemical communications (Cambridge, England)·2026

Same author

Multiple risk factors predict carotid intima media thickness in a 10 year prospective study.

Scientific reports·2026

Same author

Correction: An effective method to enhance transient gene expression by transfecting high-density CHO cells.

AMB Express·2026

Same author

An effective method to enhance transient gene expression by transfecting high-density CHO cells.

AMB Express·2025

Same author

Machine learning-based prediction of carotid intima-media thickness progression: a three-year prospective cohort study.

Frontiers in medicine·2025

Search research articles

Related Experiment Video

Updated: Jun 24, 2026

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay

Published on: February 6, 2012

An X-chromosome scan reveals a locus for fat distribution in chromosome region Xp21-22.

R Arlen Price¹, Wei-Dong Li, Robin Kilker

¹Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6140, USA. arlen@bgl.psycha.upenn.edu

|May 29, 2002

Summary

This summary is machine-generated.

Researchers investigated the X chromosome for obesity links, finding suggestive evidence for waist-to-hip ratio (WHR) in women. This genetic locus may influence female fat distribution on chromosome Xp21-22.

More Related Videos

Hyperpolarized Xenon for NMR and MRI Applications

Hyperpolarized Xenon for NMR and MRI Applications

Published on: September 6, 2012

A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene

A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene

Published on: September 16, 2019

Related Experiment Videos

Last Updated: Jun 24, 2026

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay

Published on: February 6, 2012

Hyperpolarized Xenon for NMR and MRI Applications

Hyperpolarized Xenon for NMR and MRI Applications

Published on: September 6, 2012

A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene

A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene

Published on: September 16, 2019

Area of Science:

Genetics
Human Obesity Research
Medical Genetics

Background:

Previous genome scans for obesity primarily focused on autosomes.
Limited research has explored the X chromosome's role in human obesity.
Conflicting findings exist regarding X chromosome linkage to obesity phenotypes.

Purpose of the Study:

To investigate the X chromosome for quantitative trait loci (QTLs) associated with obesity and related phenotypes.
To examine linkage of five obesity phenotypes and two derived traits (leptin resistance, fat patterning) to X chromosome markers.
To analyze data from independent European-American and African-American family cohorts.

Main Methods:

Genome-wide scan of the X chromosome using 20 markers in 190 European-American and 43 African-American families.
Analysis of body mass index (BMI), body fat percentage, hip and waist circumferences, plasma leptin, leptin resistance, and waist-to-hip ratio (WHR).
Nonparametric linkage analyses adjusted for age, race, and sex, with suggestive linkage defined by specific Z score thresholds.

Main Results:

Suggestive linkage was identified exclusively for WHR, indicating a potential QTL for fat distribution.
Linkage signals were detected in both family sets, with stronger evidence in females.
The identified linkage region on Xp21-22, while significant, is broad and distinct from previously reported intervals.

Conclusions:

A QTL influencing female fat distribution may be located in the Xp21-22 region.
The findings support further investigation of the X chromosome in obesity research, particularly in women.
Divergent results highlight the need for replication and examination of the X chromosome by other research groups.