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Symptomatic and asymptomatic benign prostatic hyperplasia: molecular differentiation by using microarrays.
Kulkarni Prakash1, Gregorio Pirozzi, Michael Elashoff
1Gene Logic Inc., 708 Quince Orchard Road, Gaithersburg, MD 20878, USA.
Summary
Benign prostatic hyperplasia (BPH) gene expression differs between symptomatic and asymptomatic forms. This genetic signature may offer new ways to treat BPH symptoms and hyperplasia in aging men.
Area of Science:
- Urology
- Molecular Biology
- Genetics
Background:
- Benign prostatic hyperplasia (BPH) significantly impacts aging men's quality of life.
- The etiology of BPH is largely unknown.
- Histologic BPH can manifest as either symptomatic or asymptomatic.
Purpose of the Study:
- To identify molecular differences between symptomatic and asymptomatic BPH.
- To analyze gene expression profiles in prostate transition zone tissue.
Main Methods:
- Microarray analysis was used to examine gene expression.
- Prostate transition zone tissue samples were analyzed.
Main Results:
- A distinct set of 511 differentially expressed genes was identified.
- This genetic signature effectively distinguishes BPH from normal prostate tissue.
- The genetic signature did not appear to change with age.
Conclusions:
- The identified genetic signature provides insight into BPH molecular differences.
- These findings may lead to novel therapeutic approaches for BPH symptoms and hyperplasia.