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Related Experiment Videos

Voluntarily simulated tremor in normal subjects.

Pierre R Burkhard1, J William Langston, James W Tetrud

  • 1Parkinson's Institute, Sunnyvale, California, USA.

Neurophysiologie Clinique = Clinical Neurophysiology
|May 31, 2002
PubMed
Summary

Normal subjects can voluntarily simulate tremors (VST) that closely resemble Parkinson's disease (PD) and Essential Tremor (ET) in frequency and regularity. This suggests shared central oscillatory networks may underlie various tremor types.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Movement Disorders

Background:

  • Pathological tremors in Parkinson's disease (PD) and Essential Tremor (ET) are thought to originate from central oscillatory neuronal networks.
  • Investigating tremors in healthy individuals may provide insights into the mechanisms of pathological tremors.

Purpose of the Study:

  • To compare the neurophysiological characteristics of voluntarily simulated tremor (VST) in normal subjects with pathological tremors in PD and ET patients.
  • To test the hypothesis that similar central oscillatory networks influence both normal and pathological tremors.

Main Methods:

  • 47 neurologically intact subjects performed VST; data compared with resting tremor from 10 PD patients and postural tremor from 10 ET patients.
  • A tremor analysis system using a gyroscopic sensor measured tremor frequency, amplitude, and regularity.

Related Experiment Videos

  • Inertial loading and test-retest analyses were conducted.

    • Main Results:

    • VST in normal subjects was indistinguishable in frequency and regularity from PD and ET tremors, but had higher amplitude.
    • VST frequency, like pathological tremors, was influenced by age but not gender or handedness.
    • Inertial load did not alter tremor frequency, indicating minor mechanical influence; a logarithmic inverse relationship between VST frequency and amplitude was observed.

    Conclusions:

    • Voluntarily simulated tremor shares significant neurophysiological similarities with pathological tremors.
    • These findings support the hypothesis that common central oscillators may be involved in various tremor types, becoming clinically apparent in conditions like PD and ET.