Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

LDL-cholesterol and HDL-cholesterol concentrations decrease during the day.

Takashi Miida1, Yuichi Nakamura, Toru Mezaki

  • 1Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Japan. miida@med.niigata-u.ac.jp

Annals of Clinical Biochemistry
|June 1, 2002
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stroke-specific Movement Patterns During Passage Through a Narrow-Opening: A Cross-Sectional Study.

NeuroRehabilitation·2026
Same author

Clinical Utility of Postoperative Day 1 Technetium-99m Mercaptoacetyltriglycine Scintigraphy for Early Assessment of Graft Function in Living Donor Kidney Transplant Recipients.

Journal of transplantation·2026
Same author

Association between corticosteroid therapy during acute COVID-19 and Long COVID symptoms: a propensity score overlap-weighted analysis.

Respiratory medicine·2026
Same author

The global surgical workforce crisis: narrative review of the role of surgical educator development and technological innovations.

Surgery today·2026
Same author

Ambivalent Tolman: Indirect Influence on Enactivism of Tolman's Sign-Gestaltism Through Merleau-Ponty.

Journal of the history of the behavioral sciences·2026
Same author

Active Surveillance for Localized Prostate Cancer: A Retrospective Single-Center Study.

International journal of urology : official journal of the Japanese Urological Association·2026

Low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels significantly decrease throughout the day after meals. These lipid levels return to baseline the following morning.

Area of Science:

  • Clinical Chemistry
  • Cardiovascular Disease Biomarkers
  • Lipid Metabolism

Background:

  • Homogeneous assays provide accurate measurements of LDL-C and HDL-C with minimal triglyceride interference.
  • Previous research indicated a potential postprandial decline in LDL-C levels.
  • Understanding diurnal variations in lipid profiles is crucial for cardiovascular health assessment.

Purpose of the Study:

  • To investigate whether LDL-C and HDL-C exhibit significant diurnal variations.
  • To quantify the extent of postprandial changes in LDL-C and HDL-C in different subject groups.

Main Methods:

  • Employed homogeneous assays to determine daily profiles of LDL-C and HDL-C.
  • Studied two groups: individuals with normal coronary arteries (N=10) and those with coronary artery disease (CAD, N=23).

Related Experiment Videos

  • Collected blood samples to measure lipid levels at various time points throughout the day.

    • Main Results:

    • Both LDL-C and HDL-C levels were significantly reduced after breakfast until midnight compared to pre-breakfast levels in both normal and CAD groups.
    • The mean reduction in LDL-C ranged from 0.09-0.13 mmol/L in normal subjects and 0.05-0.20 mmol/L in CAD patients.
    • The mean reduction in HDL-C was 0.02-0.06 mmol/L in normal subjects and 0.00-0.05 mmol/L in CAD patients.

    Conclusions:

    • LDL-C and HDL-C concentrations demonstrate a significant decrease over the course of a day.
    • These diurnal fluctuations in lipid levels are observed in both healthy individuals and those with coronary artery disease.
    • The findings highlight the importance of considering the timing of blood draws for accurate lipid level interpretation.