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LDL-cholesterol and HDL-cholesterol concentrations decrease during the day
Takashi Miida1, Yuichi Nakamura, Toru Mezaki
1Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Japan. miida@med.niigata-u.ac.jp
Background:
Homogenous assays for LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) are highly accurate, with little interference from triglyceride. Using these methods, we measured postprandial LDL-C and HDL-C. Earlier studies suggested a postprandial decrease in LDL-C.
Methods:
To elucidate whether LDL-C and HDL-C decrease significantly during the day, we determined daily profiles of LDL-C and HDL-C using homogeneous assays in subjects with normal coronary arteries (N; n=10), and subjects with coronary artery disease (CAD; n=23).
Results:
In both groups, LDL-C and HDL-C were significantly lower from after breakfast until midnight than they were before breakfast. The next morning, they returned to baseline levels. The mean reduction in LDL-C was 0.09-0.13 mmol/L in N and 0.05-0.20 mmol/L in CAD, while that in HDL-C was 0.02-0.06 mmol/L in N and 0.00-0.05 mmol/L in CAD.
Conclusion:
LDL-C and HDL-C decrease significantly over the course of the day.