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Related Experiment Videos

A custom mandibular distraction device for the rat.

John P Connolly1, Zi-Jun Liu, Lingli Wang

  • 1Division of Plastic Surgery, Department of Surgery, University of Washington School of Medicine, Seattle 98105, USA.

The Journal of Craniofacial Surgery
|June 1, 2002
PubMed
Summary
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A new custom external device for rat mandible distraction osteogenesis (DO) offers a reliable, cost-effective model. This reproducible method facilitates histologic and biochemical investigations of DO in rats.

Area of Science:

  • Biomaterials and Regenerative Medicine
  • Surgical Innovation
  • Animal Models in Research

Background:

  • Distraction osteogenesis (DO) is a critical process for bone regeneration.
  • The rat mandible is a valuable model for studying DO due to cost and reagent availability.
  • Existing models may have limitations in terms of cost, complexity, or reproducibility.

Purpose of the Study:

  • To develop and evaluate a novel, custom external device for distraction osteogenesis in the rat mandible.
  • To establish a reproducible and reliable animal model for investigating the histologic and biochemical aspects of DO.
  • To assess the safety, efficacy, and tolerability of the new device in Sprague-Dawley rats.

Main Methods:

  • Development of a custom external device using a jackscrew, microplates, microscrews, and a methylmethacrylate block.

Related Experiment Videos

  • Surgical placement of the device on the mandibular ramus of 153 Sprague-Dawley rats using sterile techniques.
  • Monitoring of postoperative outcomes, including mortality, wound complications, device stability, and animal recovery.

    • Main Results:

    • The custom device demonstrated good positioning and callus formation in postmortem examinations.
    • Low incidence of device dislodgment (0%) and wound infection (0%) was observed.
    • Postoperative mortality was 11%, primarily due to anesthetic complications; 4% experienced mandible fracture during device placement.
    • Rats recovered preoperative weight within an average of 9.2 days, indicating good tolerability.

    Conclusions:

    • The developed custom external device provides a small, reproducible, and effective model for rat mandible distraction osteogenesis.
    • This model minimizes the need for extensive surgical undermining and shows a low rate of complications.
    • The model is suitable for detailed histologic and biochemical investigations of DO, offering advantages over existing methods.