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Modes of neuronal migration in the developing cerebral cortex.

Bagirathy Nadarajah1, John G Parnavelas

  • 1Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. b.nadarajah@ucl.ac.uk

Nature Reviews. Neuroscience
|June 4, 2002
PubMed
Summary

Neurons migrate to form the developing cortex using distinct methods. Early neurons use somal translocation, while later pyramidal cells use glia-guided locomotion, and interneurons migrate tangentially then radially.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Cortical formation involves postmitotic neuron migration from the ventricular zone.
  • Radial glial cells traditionally guide neuronal migration.
  • Recent evidence suggests diverse migration modes for different neuron types.

Purpose of the Study:

  • To review and synthesize evidence for distinct neuronal migration modes in cortical development.
  • To differentiate between somal translocation, glia-guided locomotion, and tangential migration of interneurons.

Main Methods:

  • Review of existing literature on neuronal migration in the developing cortex.
  • Analysis of studies detailing the movement patterns of various neuronal populations.

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Main Results:

  • Two primary radial migration modes identified: somal translocation (early neurons) and glia-guided locomotion (pyramidal cells).
  • Cortical interneurons exhibit a unique tangential and subsequent radial migration pattern.
  • Neuronal migration strategies are diverse and cell-type specific.

Conclusions:

  • The developing cortex is formed by neurons employing multiple, distinct migration strategies.
  • Understanding these diverse migration modes is crucial for comprehending cortical development and organization.
  • This review highlights the complexity of neuronal positioning in the brain.