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Preparation and antibacterial activity of 3-methyl-1-p-substituted phenylpyrazole-5-thiol
Yoshinobu Tagawa1, Shin'ichi Minami, Toshio Yoshida
1Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. tagawa@fukuoka-u.ac.jp
Archiv Der Pharmazie
|June 5, 2002
Abstract:
3-Methyl-1-phenylpyrazole-5-thiol (3a) and its p-nitro- (5) and p-fluorophenyl (8) derivatives were prepared as potential antimicrobial agents in relatively good yields. Compounds 3a and 8 showed good antibacterial activities against MRSA, S. aureus, S. epidermidis, E. faecalis, E. faecium, and S. pyogenes. Moreover, compound 3a also showed a synergistic effect with some aminoglycosides.