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Concise synthesis and enzymatic resolution of L-(+)-homophenylalanine hydrochloride
Hua Zhao1, Robert G Luo, Dean Wei
1Department of Chemical Engineering, Chemistry and Environmental Science, New Jersey Institute of Technology, University Heights, Newark 07102, USA.
Enantiomer
|June 5, 2002
Abstract:
The N-acetyl-homophenylalanine ethyl ester was synthesized by a simple three-step-reaction strategy. L-(+)-homophenylalanine hydrochloride with 98% ee was obtained through a kinetic resolution process using industrial enzyme alcalase. Compared with other methods, this strategy has the advantage of economical and simple procedure giving high product optical purity.