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Dissolution tests for self-setting calcium phosphate cement-containing nifedipine.
Toyofumi Suzuki1, Kifumi Arai, Hiroko Goto
1Department of Pharmaceutics, College of Pharmacy, Nihon University, Chiba, Japan.
Chemical & Pharmaceutical Bulletin
|June 5, 2002
Summary
Nifedipine-containing calcium phosphate cement (CPC) allows for controlled release of nifedipine (NF) over 7 days or longer. Release patterns followed the Higuchi equation, though constants varied with dissolution testing methods.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Pharmaceutical Science
Background:
- Calcium phosphate cement (CPC) is a versatile biomaterial.
- Controlled drug delivery systems are crucial for therapeutic efficacy.
- Nifedipine (NF) is a widely used cardiovascular drug.
Purpose of the Study:
- To prepare nifedipine-containing calcium phosphate cement (CPC).
- To evaluate the in vitro release kinetics of nifedipine from the CPC preparation.
- To compare different dissolution testing methods for nifedipine release from CPC.
Main Methods:
- Preparation of nifedipine-loaded CPC.
- In vitro drug release studies using the shaking method (SK), Japanese Pharmacopoeia XIV (JPXIV) paddle method (PD), and JPXIV flow-through cell method (FT).
- Analysis of release kinetics using the Higuchi equation.
Main Results:
- Nifedipine release from CPC was sustained for 7 days or longer across all tested methods.
- The release profiles of nifedipine from CPC followed the Higuchi equation.
- The Higuchi constant varied among the SK, PD, and FT methods, likely due to differences in the apparent tortuosity (tau) of the cement's capillary system.
Conclusions:
- Nifedipine-containing CPC formulations enable controlled nifedipine release.
- The choice of dissolution testing method can influence the observed release kinetics parameters.
- CPC is a promising platform for developing sustained-release drug delivery systems.