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Updated: Aug 12, 2026

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries
Published on: February 25, 2016
The nitric oxide pathway and oxidative stress in heart failure
1Emory University School of Medicine, Department of Medicine, Division of Cardiology, Atlanta, GA 30322, USA. csearle@emory.edu
Abstract:
Chronic heart failure is associated with pathophysiologic alterations in myocardial and vascular function. Accompanying these changes are increased oxidative stress and modulation of the nitric oxide pathway. The role of the nitric oxide(.) pathway in heart failure and the effect of its interaction with reactive oxygen species are complex, with diverse pathophysiologic implications in both the heart and the peripheral vasculature. This review discusses current information regarding the nitric oxide(.) pathway in heart failure and its relationship with increased oxidative stress.
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