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In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
Published on: June 15, 2018
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MicroRNAs and Cardiovascular Disease Risk
1Emory University School of Medicine and Atlanta VA Health Care System, 1670 Clairmont Road, Decatur, GA, 30033, USA. csearle@emory.edu.
Current Cardiology Reports
|January 11, 2024
Summary
Extracellular microRNAs (miRNAs) show promise as non-invasive biomarkers for cardiovascular disease risk and prognosis. However, standardized methods are needed to improve reproducibility for clinical application.
Area of Science:
- Cardiovascular Biology
- Molecular Diagnostics
- Biomarker Discovery
Background:
- MicroRNAs (miRNAs) are short, non-coding RNAs crucial in cardiovascular biology.
- Altered intracellular miRNA expression is linked to cardiovascular disease (CVD) development.
- Extracellular miRNAs in blood offer potential as non-invasive CVD biomarkers.
Purpose of the Study:
- To review current knowledge on miRNAs as biomarkers for cardiovascular disease risk and prognosis.
- To summarize the potential of extracellular miRNAs in assessing CVD risk.
- To highlight challenges and future directions for miRNA biomarker application.
Main Methods:
- Literature review of studies investigating extracellular miRNAs and cardiovascular disease.
- Analysis of associations between miRNA profiles and CVD risk stratification.
- Evaluation of methodological factors affecting reproducibility.
Main Results:
- Numerous studies link extracellular miRNA profiles to cardiovascular disease.
- Extracellular miRNAs show potential for CVD risk stratification.
- Poor reproducibility due to methodological differences hinders clinical application.
Conclusions:
- Circulating extracellular miRNAs are promising biomarkers for cardiovascular disease.
- Standardized methods are essential for reliable clinical implementation.
- Larger, well-designed studies are needed to validate miRNA biomarkers.
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