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Related Experiment Videos

Progress in high throughput SNP genotyping methods.

Z Tsuchihashi1, N C Dracopoli

  • 1Clinical Discovery Technologies, Bristol-Myers Squibb Co, Princeton, NJ 08543-5400, USA. zenta.tsuchihashi@bms.com

The Pharmacogenomics Journal
|June 7, 2002
PubMed
Summary

Single nucleotide polymorphism (SNP) genotyping is advancing rapidly, offering faster and cheaper methods for large-scale genetic studies. These technological improvements pave the way for future whole genome association studies.

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Area of Science:

  • Genetics
  • Biotechnology

Background:

  • Current single nucleotide polymorphism (SNP) genotyping methods are often too slow and costly for extensive genetic association studies.
  • Large-scale studies require high-throughput genotyping for hundreds of SNPs across numerous DNA samples.

Purpose of the Study:

  • To review recent technological advancements in high-throughput SNP genotyping.
  • To discuss emerging faster and more cost-effective methods.

Main Methods:

  • Review of current and novel SNP genotyping technologies.
  • Analysis of technical progress in the field over recent years.

Main Results:

  • Significant progress has been made in developing faster and cheaper SNP genotyping methods.

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  • Emerging technologies are addressing the limitations of existing methods for high-throughput applications.

    • Conclusions:

    • Rapid technological progress in SNP genotyping is making large-scale genetic studies more feasible.
    • Advancements, coupled with SNP discovery and haplotype mapping, may soon enable whole genome association studies.