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Synthesis of cyclosporin A-derived affinity reagents by olefin metathesis
Jason A Smulik1, Steven T Diver, Fan Pan
1Department of Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Organic Letters
|June 7, 2002
Abstract:
[reaction: see text] New affinity reagents were synthesized using alkene metathesis to directly modify the MeBmt side chain of cyclosporin A. The reagents were used to detect novel cyclophilins from cellular extracts.