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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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Mushroom-shaped choroidal recurrence of retinoblastoma 25 years after therapy

Carol L Shields1, Michelle R Piccone, Jerry A Shields

  • 1Ocular Oncology Service, Wills Eye Hospital, 900 Walnut St, Philadelphia, PA 19107, USA.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|June 7, 2002
PubMed
Abstract

No abstract available in PubMed .

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...