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Endocannabinoids in cognition and dependence.

A H Lichtman1, S A Varvel, B R Martin

  • 1Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298-0613, USA. alichtma@hsc.vcu.edu

Prostaglandins, Leukotrienes, and Essential Fatty Acids
|June 8, 2002
PubMed
Summary

The endocannabinoid system influences cognition and drug dependence. Research using CB(1) receptor antagonists and knockout models shows this system modulates memory and opioid dependence.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Cognitive Science

Background:

  • Cannabis use has diverse pharmacological effects, including cognitive deficits and withdrawal symptoms.
  • The hippocampus, crucial for memory, shows altered neurochemistry (glutamatergic, GABAergic, cholinergic) during acute intoxication.
  • The endocannabinoid system, particularly the CB(1) receptor, is implicated in cognitive function and drug dependence.

Purpose of the Study:

  • To review recent advances in understanding the endocannabinoid system's role in cognition.
  • To explore the endocannabinoid system's involvement in drug dependence, including opioid dependence.

Main Methods:

  • Utilizing CB(1) cannabinoid receptor antagonist SR141716A in pharmacological studies.
  • Employing transgenic mice lacking the CB(1) receptor (knockout models).

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  • Analyzing performance in various memory tasks.

    • Main Results:

    • Enhanced performance in memory tasks was observed with SR141716A treatment.
    • CB(1) receptor knockout mice demonstrated improved cognitive task performance.
    • Evidence suggests the endocannabinoid system modulates opioid dependence.

    Conclusions:

    • The endocannabinoid system plays a significant role in modulating cognitive functions, particularly memory.
    • This system is a key target for understanding and potentially treating drug dependence.
    • Further research is needed to fully elucidate the endocannabinoid system's complex roles.