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Calibration of a subcutaneous amperometric glucose sensor implanted for 7 days in diabetic patients. Part 2.
C Choleau1, J C Klein, G Reach
1INSERM U341, Diabetes Department, Hôtel-Dieu Hospital, 1 Place du Parvis Notre Dame, 75004, Paris, France.
Unlabelled:
Calibration, i.e. the transformation in real time of the signal I(t) generated by the glucose sensor at time t into an estimation of glucose concentration G(t), represents a key issue for the development of a continuous glucose monitoring system.
Objective:
To compare two calibration procedures. In the one-point calibration, which assumes that I(o) is negligible, S is simply determined as the ratio I/G, and G(t) = I(t)/S. The two-point calibration consists in the determination of a sensor sensitivity S and of a background current I(o) by plotting two values of the sensor signal versus the concomitant blood glucose concentrations. The subsequent estimation of G(t) is given by G(t) = (I(t)-I(o))/S.
Research Design And Methods:
A glucose sensor was implanted in the abdominal subcutaneous tissue of nine type 1 diabetic patients during 3 (n = 2) and 7 days (n = 7). The one-point calibration was performed a posteriori either once per day before breakfast, or twice per day before breakfast and dinner, or three times per day before each meal. The two-point calibration was performed each morning during breakfast.
Results:
The percentages of points present in zones A and B of the Clarke Error Grid were significantly higher when the system was calibrated using the one-point calibration. Use of two one-point calibrations per day before meals was virtually as accurate as three one-point calibrations.
Conclusion:
This study demonstrates the feasibility of a simple method for calibrating a continuous glucose monitoring system.
