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Updated: Aug 12, 2026

Forward Genetic Approach to Uncover Stress Resistance Genes in Mice — A High-throughput Screen in ES Cells
Published on: November 11, 2015
LEDGF, a survival factor, activates stress-related genes
Toshimichi Shinohara1, Dhirendra P Singh, Nigar Fatma
1Brigham and Women's Hospital, Department of Ophthalmology, Center for Ophthalmic Research, Harvard Medical School, Boston, MA 02115, USA. tshinohara@rics.bwh.harvard.edu
Abstract:
LEDGF is a survival factor and it enhances survival of various cell types against stress. LEDGF is also a transcriptional activator and it binds to promoter elements of heat shock and stress-related genes to activate expression of these genes. The elevated levels of the stress-related family of proteins, such as heat shock proteins, antioxidant proteins, and detoxication enzymes might suppress apoptosis induced by stress. The protective mechanisms against stress in mammalian cells and in yeast are surprisingly similar.
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