Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Memory T-cells in non-lymphoid tissues.

Linda S Cauley1, Robert J Hogan, David L Woodland

  • 1The Trudeau Institute, Saranac Lake, NY 12983, USA.

Current Opinion in Investigational Drugs (London, England : 2000)
|June 11, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intranasal PIV5-vectored SARS-COV-2 KP.2 vaccine protects against homologous and heterologous challenge in mice and hamsters.

Vaccine·2026
Same author

Assay development and screening of inhibitors targeting the SARS-CoV-2 2'-O-methyltransferase NSP16.

Pharmaceutical science advances·2026
Same author

Immunology Research in Latin America.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·2025
Same author

Genetic variation of hemolysin co-regulated protein 1 affects the immunogenicity and pathogenicity of Burkholderia pseudomallei.

PLoS neglected tropical diseases·2025
Same author

A Message from Editor-in-Chief David L. Woodland.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·2024
Same author

Validation of Saliva as the Clinical Specimen Type for a University-Wide COVID-19 Surveillance Program.

Viruses·2024

Scientists discovered two types of memory CD8 T-cells. One type resides in lymph organs, while another is found in tissues. Targeting tissue-resident T-cells could improve vaccines against viral infections.

Area of Science:

  • Immunology
  • Cellular Biology
  • Virology

Background:

  • Long-lived memory CD8 T-cells are crucial for adaptive immunity.
  • Memory CD8 T-cell populations have been traditionally studied within lymphoid organs.
  • Recent research indicates the existence of distinct memory CD8 T-cell subsets in non-lymphoid tissues.

Purpose of the Study:

  • To investigate the characteristics and location of memory CD8 T-cell subsets.
  • To explore the potential of targeting non-lymphoid tissue-resident memory T-cells for vaccine development.

Main Methods:

  • Analysis of memory CD8 T-cell populations in lymphoid and non-lymphoid tissues.
  • Utilizing respiratory virus models to assess cellular immunity.
  • Correlating T-cell numbers in lung tissue with protective immunity.

Related Experiment Videos

Main Results:

  • Memory CD8 T-cell populations can be divided into at least two distinct subsets.
  • A subset of partially activated memory CD8 T-cells resides in non-lymphoid tissues.
  • Higher numbers of antigen-specific T-cells in lung tissue correlate with effective immunity in respiratory virus models.

Conclusions:

  • Memory CD8 T-cells exhibit heterogeneity in location and activation state.
  • Boosting memory T-cell populations in non-lymphoid tissues represents a promising strategy for enhancing vaccine efficacy against viral infections.