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Memory T-cells in non-lymphoid tissues
Linda S Cauley1, Robert J Hogan, David L Woodland
1The Trudeau Institute, Saranac Lake, NY 12983, USA.
Recent studies have shown that long-lived memory CD8 T-cell populations can be subdivided into two distinct groups. The central pool of resting memory cells in lymph organs has been extensively analyzed. However, a second subset of partially activated CD8 memory T-cells has recently been identified in non-lymphoid tissues. In respiratory virus models, a strong correlation between the numbers of antigen-specific T-cells in lung tissues and effective protective cellular immunity suggests that boosting the numbers of memory T-cells in non-lymphoid tissues may be a fruitful approach in vaccine development for viral infections.
Recent studies have shown that long-lived memory CD8 T-cell populations can be subdivided into two distinct groups. The central pool of resting memory cells in lymph organs has been extensively analyzed. However, a second subset of partially activated CD8 memory T-cells has recently been identified in non-lymphoid tissues. In respiratory virus models, a strong correlation between the numbers of antigen-specific T-cells in lung tissues and effective protective cellular immunity suggests that boosting the numbers of memory T-cells in non-lymphoid tissues may be a fruitful approach in vaccine development for viral infections.