Related Experiment Videos
First total synthesis of A(2) isoprostane
Giuseppe Zanoni1, Alessio Porta, Giovanni Vidari
1Department of Organic Chemistry, University of Pavia, Viale Taramelli, 10, 27100, Italy. gzanoni@unipv.it
The Journal of Organic Chemistry
|June 11, 2002
Abstract:
A stereoselective Julia-Lythgoe olefination has allowed the first total synthesis of A(2) isoprostane (1), a recently discovered member of the growing isoprostane family. This elusive compound opens up numerous new avenues for the molecular biology of cyclopentenone prostaglandins, which are endowed of intriguing biological effects such as antitumor, antiinflammatory, and antiviral activities.