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[Ciclosporin].

M S Doutre1

  • 1Service de Dermatologie, Hôpital Haut-Lévêque, CHU de Bordeaux, 33604 Pessac, France. marie-sylvie.doutre@chu-bordeaux.fr

Annales De Dermatologie Et De Venereologie
|June 11, 2002
PubMed
Summary
This summary is machine-generated.

Ciclosporin, an immunosuppressant, is effective for organ transplant rejection and immune-related diseases like psoriasis. Newer formulations offer improved absorption, but potential side effects like nephrotoxicity require careful monitoring.

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Area of Science:

  • Immunology
  • Pharmacology

Context:

  • Ciclosporin, derived from Tolypocladium inflatum GAMS, possesses significant immunosuppressive capabilities.
  • It functions by inhibiting T-cell activation and cytokine gene transcription, notably interleukin-2.

Purpose:

  • To review the efficacy and safety of ciclosporin, particularly in organ transplantation and dermatological conditions.
  • To highlight the advantages of newer formulations like Neoral(R) over traditional ones regarding bioavailability.

Summary:

  • Ciclosporin is a key agent in preventing organ transplant rejection and treating immune-related disorders.
  • Its effectiveness in severe psoriasis and atopic dermatitis is supported by clinical studies.
  • While generally beneficial, ciclosporin carries risks of nephrotoxicity, hypertension, and other adverse effects, necessitating vigilant patient management.

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Impact:

  • Ciclosporin has transformed organ transplantation outcomes and offers therapeutic options for various immune-mediated diseases.
  • Improved formulations enhance patient compliance and treatment consistency.
  • Understanding its adverse effect profile is crucial for safe and effective clinical application.