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Mechanisms of pathogenesis: differences amongst Leishmania species

Maria Colmenares1, Sujata Kar, Karen Goldsmith-Pestana

  • 1Yale University School of Medicine, Department of Epidemiology and Public Health, P.O. Box 208034, 60 College Street, New Haven, CT 06520-8034, USA.

Transactions of the Royal Society of Tropical Medicine and Hygiene
|June 12, 2002
PubMed

One of the features of the genus Leishmania is the diversity of tropism/disease resulting from infection. With notable exceptions, the form (visceral, cutaneous, diffuse cutaneous, mucocutaneous) and severity of disease is a function of the infecting Leishmania species together with host genetics and consequent inflammatory and immune responses. It has become evident from genetic and immunological studies using the murine model that the various members of the genus Leishmania differ in aspects of their 'approach' to the host immune system. We are just beginning to appreciate the complexities of these interactions, which have import for the development of a vaccine against leishmaniasis. In this paper, what is currently understood concerning the mechanisms of leishmanial pathogenesis (based upon studies employing the murine model) is briefly summarized.

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