Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Advanced larynx cancer.

Scott E Strome1, Eric C Weinman

  • 1Mayo Clinic, Department of Otorhinolaryngology, 200 First Street SW, Rochester, MN 55906, USA. strome.scott@mayo.edu

Current Treatment Options in Oncology
|June 12, 2002
PubMed
Summary

Stage III-IV laryngeal cancer survival has not improved due to treatment controversies. Conservation laryngeal surgery is recommended for eligible patients, with organ preservation as a primary option for others.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DNAJB1-PRKACA fusion neoantigens elicit rare endogenous T cell responses that potentiate cell therapy for fibrolamellar carcinoma.

Cell reports. Medicine·2024
Same author

Fc multimers effectively treat murine models of multiple sclerosis.

Frontiers in immunology·2023
Same author

Complement component C1q is an immunological rheostat that regulates Fc:Fc<math> </math>R interactions.

Immunogenetics·2023
Same author

NK cell expression of Tim-3: First impressions matter.

Immunobiology·2019
Same author

Intratumor genetic heterogeneity in squamous cell carcinoma of the oral cavity.

Head & neck·2019
Same author

The evolving role of immuno-oncology for the treatment of head and neck cancer.

Laryngoscope investigative otolaryngology·2019

Area of Science:

  • Oncology
  • Otolaryngology
  • Surgical Oncology

Background:

  • Prognosis for advanced laryngeal cancer (stage III-IV) has remained stagnant for 40 years.
  • Treatment failure is linked to heterogeneous patient/tumor populations and lack of comparative trials.
  • Standardized quality-of-life measures and organ preservation approaches complicate treatment decisions.

Purpose of the Study:

  • To review current treatment strategies for advanced laryngeal cancer.
  • To emphasize the role of conservation surgery and organ preservation.
  • To highlight the importance of patient-centered decision-making.

Main Methods:

  • Literature review and expert opinion synthesis.
  • Discussion of treatment controversies and outcome measures.
  • Analysis of organ preservation vs. total laryngectomy.

Main Results:

  • No significant improvement in survival for stage III-IV laryngeal cancer over four decades.
  • Lack of randomized trials and standardized quality-of-life metrics hinder optimal treatment selection.
  • Conservation laryngeal surgery is proposed as a primary approach for suitable candidates.

Conclusions:

  • Conservation laryngeal surgery should be the mainstay for select advanced laryngeal cancer patients.
  • Organ preservation strategies are valuable primary options for patients not suitable for conservation surgery.
  • Informed patient consent and quality-of-life considerations are crucial for treatment planning.

Related Experiment Videos