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Updated: Sep 30, 2026

In Vitro Evaluation of the Potentiating Effects of Plant-Derived Molecules on Conventional Biocides
Published on: May 8, 2026
[Antimycobacterial effects of pyrrolidinoethylester alkoxysubstituted phenylcarbamic acids]
K Waisser1, J Cizmárik, K Drazková
1Katedra anorganické a organické chemie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové. waisser@faf.cuni.cz
Abstract:
Pyrrolidinoethylesters of alkoxysubstituted phenylcarbamic acids, formerly investigated for local anaesthetic activity, can be considered to be potential antituberculotics. They are effective in vitro against Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobacterium avium. Their effect increases with the length of the alkyl chain in the alkoxy group bound to the phenyl. The influence of the position of the alkoxyl chain on the phenyl is not too marked, but it seems to decrease in the series m-, p-, o-.
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