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Published on: October 12, 2017
Lipoprotein(a) was an independent predictor for major coronary events in treated hypertensive men
Stefan Agewall1, Björn Fagerberg
1Department of Cardiology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden. stefan.agewall@cardiol.hs.sll.se
Insights
In treated hypertensive men, elevated Lipoprotein(a) levels predict major coronary events, including heart attack and sudden death. This finding highlights Lipoprotein(a) as a key indicator for cardiovascular risk.
Area of Science:
- Cardiology
- Preventive Medicine
- Biomarkers
Background:
- Lipoprotein(a) is implicated in coronary heart disease development.
- Understanding its predictive role is crucial for cardiovascular risk assessment.
Purpose of the Study:
- To evaluate Lipoprotein(a) as a predictor of major coronary events.
- Assessing fatal and nonfatal myocardial infarction and sudden death risk.
Main Methods:
- Prospective study of 118 treated hypertensive men (aged 56-77) with additional risk factors.
- Lipoprotein(a) levels measured at baseline; major coronary events tracked over 3.0 years.
- Cox regression analysis used to determine independent predictors.
Main Results:
- Patients with existing coronary heart disease had higher Lipoprotein(a) levels.
- Lipoprotein(a) significantly predicted major coronary events (p=0.033).
- Lipoprotein(a) remained an independent predictor when baseline coronary disease was considered (p=0.044).
Conclusions:
- Lipoprotein(a) is an independent predictor of major coronary events in treated hypertensive men.
- This emphasizes the clinical significance of Lipoprotein(a) in cardiovascular risk stratification.
Background And Hypothesis:
Lipoprotein(a) may play a part in the development of coronary heart disease. The purpose of this prospective study was to evaluate lipoprotein(a) as a predictor of major coronary events (fatal and nonfatal myocardial infarction and sudden death).
Methods:
This was a prospective study of 118 men, aged 56 to 77 years, with treated hypertension and at least one additional cardiovascular risk factor (hypercholesterolemia, diabetes mellitus, or smoking) were included in the study. Lipoprotein(a) was measured at entry and major coronary events were followed during follow-up.
Results:
The mean observation time was 3.0 years. Fourteen patients had a major coronary event during the follow-up period. Subjects with coronary heart disease (previous myocardial infarction, angina pectoris, or major electrocardiographic changes) at entry (n = 27) had significantly higher lipoprotein(a) levels than subjects without (n = 91) known coronary heart disease (p < 0.05). Lipoprotein(a) was a significant predictor for major coronary events (p = 0.033). Furthermore, when coronary disease at entry was included into the Cox regression analysis, lipoprotein(a) was an independent predictor for major coronary events (p = 0.044).
Conclusions:
Among treated hypertensive men, lipoprotein(a) was an independent predictor of major coronary events.
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