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Distribution and function of FSH receptor genetic variants in normal men
K Asatiani1, J Gromoll, S V Eckardstein
1Institute of Reproductive Medicine of the University, Münster, Germany.
Andrologia
|June 13, 2002
Summary
Follicle stimulating hormone receptor (FSHR) gene variants do not impact male fertility parameters. This study found no significant differences in FSH levels or semen quality based on FSHR genotype in men.
Area of Science:
- Reproductive Endocrinology
- Human Genetics
- Spermatogenesis Research
Background:
- Follicle stimulating hormone (FSH) is crucial for normal spermatogenesis, acting via the FSH receptor (FSHR) on Sertoli cells.
- The specific impact of FSHR variants on male reproductive function requires further investigation.
- Understanding FSHR isoforms is key to comprehending male gamete development.
Purpose of the Study:
- To investigate the influence of two distinct FSHR isoforms (Thr307/Asn680 and Ala307/Ser680) on male reproductive parameters.
- To analyze the association between FSHR gene polymorphisms and semen quality in healthy men.
- To compare the effect of FSHR genotype on male reproductive health versus findings in females.
Main Methods:
- Retrospective analysis of 288 healthy men, including 86 previously studied fathers and 202 new subjects.
- FSHR polymorphism analysis at positions 680 (all subjects) and 307 (150 subjects) using single-stranded conformation polymorphism (SSCP) gel electrophoresis.
- Genotyping for Thr307/Asn680 and Ala307/Ser680 variants and assessment of basal FSH, testosterone, inhibin B, and semen parameters.
Main Results:
- The study determined the distribution frequencies of FSHR genotypes at positions 680 (Asn/Asn 29%, Asn-Ser 52%, Ser-Ser 19%) and 307 (Thr-Thr 27%, Ala-Thr 55%, Ala-Ala 18%).
- No significant differences were observed in basal FSH, testosterone, inhibin B levels, or semen parameters when subjects were grouped by FSHR genotype at position 680.
- Four subjects exhibited polymorphism combinations other than the common Thr307/Asn680 and Ala307/Ser680.
Conclusions:
- In contrast to findings in females, the FSHR genotype does not influence clinical parameters in males.
- The studied FSHR polymorphisms (Thr307/Asn680 and Ala307/Ser680) do not appear to affect male fertility or reproductive hormone levels.
- Further research may be needed to explore other potential genetic factors influencing male reproductive health.
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