[Specific inhibitors of cyclooxygenase type 2] ]

In the submitted review the author analyzes the ratio, function and role of two different forms of cyclooxygenases--cyclooxygenase type 1 and cyclooxygenase type 2--in the human organism. Special attention is devoted to specific inhibitors of cyclooxygenase type 2. Specific inhibition of COX-2 is associated with a lower incidence of undesirable reactions while the antiinflammatory and analgetic effect is preserved. Celecoxib and rofecoxib--the oldest representatives of drugs from this group were used in a number of clinical studies. The results of some of these studies are presented and commented.