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Neosordarin and hydroxysordarin, two new antifungal agents from Sordaria araneosa
Paolo Davoli1, Günther Engel, Andreas Werle
1Lehrbereich Biotechnologie der Universität, Kaiserslautern, Germany.
Abstract:
Two novel antifungal agents belonging to the sordarin family have been isolated from fermentations of Sordaria araneosa by bioassay-guided purification and their structures elucidated by NMR techniques. Neosordarin (1) is closely related to the recently discovered hypoxysordarin (2), with only small differences on the aliphatic side chain acylating the hydroxyl in the 3'-position of the sordarose moiety. Hydroxysordarin (3) closely resembles sordarin (4), the only slight difference being the replacement of sordarose with altrose as the sugar unit.
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Antifungal Agents
Anthelminthic Agents
Antiprotozoal Agents
Fungal Group Zygomycota
Fungal Phylum Basidiomycota
Fungal Phylum Microsporidia
