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Audit of aminoglycosides usage
M Ramesh1, Siby John, D Narayanappa
1Department of Pharmacy Practice, JSS College of Pharmacy, Mysore, India. madhanramesh@hotmail.com
Insights
This study assessed aminoglycoside use in pediatric patients, finding appropriate usage for indication (72%) and dose (86%), but lower rates for safety (43%). Guidelines aim to improve pediatric antibiotic stewardship.
Area of Science:
- Pharmacology
- Pediatric Medicine
- Infectious Diseases
Background:
- Aminoglycosides are crucial antibiotics in pediatric care.
- Evaluating their appropriate use is essential for patient safety and antimicrobial stewardship.
- Previous studies highlight variability in aminoglycoside prescribing patterns.
Purpose of the Study:
- To evaluate the appropriateness of aminoglycoside usage in pediatric patients.
- To identify areas for improvement in prescribing practices.
- To assess adherence to established guidelines for aminoglycoside therapy.
Main Methods:
- Retrospective review of pediatric patients (<12 years) receiving parenteral aminoglycosides.
- Data collected over a six-month period at J.S.S. Hospital, Mysore.
- Appropriateness assessed across indication, dose, duration, safety, and cost-effectiveness.
Main Results:
- Overall appropriateness varied: indication (72%), dose (86%), duration (85%), safety (43%), cost-effectiveness (53%).
- Gentamicin was the most frequently used aminoglycoside (53%).
- Respiratory tract infections were the most common indication (50%).
Conclusions:
- Judicious use of aminoglycosides is encouraged among pediatricians.
- Implementation of aminoglycoside guidelines can enhance pediatric patient care.
- Focus on improving safety and cost-effectiveness in aminoglycoside prescribing is needed.
Objective:
This study was aimed to evaluate the usage patterns of aminoglycosides in pediatric patients for their appropriateness.
Methods:
A retrospective review was conducted over a period of six months at J.S.S. Hospital, Mysore. Patients who received parenteral aminoglycosides and below the age of 12 years were included in this study.
Results:
A total of 197 pediatric patients were evaluated for the appropriateness and was found to be 72%, 86%, 85%, 43% & 53% for indication, dose, duration, safety and cost effectiveness respectively. Majority of the patients were treated with gentamicin (53%). The most frequent indication was respiratory tract infections (50%).
Conclusion:
Effort was made to encourage judicious and quality use of aminoglycosides among the pediatricians of J.S.S. Hospital to ensure better patient care by implementation of the aminoglycosides guidelines.