Related Experiment Videos
Looking over the edge: a new role for Ena/VASP proteins in lamellipodial dynamics
James D Sutherland1, Michael Way
1Cell Motility Laboratory, Cancer Research UK.
Developmental Cell
|June 14, 2002
Abstract:
How can Ena/VASP proteins promote actin-based movement of the intracellular pathogen Listeria or rapid protrusion of lamellipodia but at the same time inhibit cell translocation? A report in the May 17(th) issue of Cell now offers a possible explanation for this conundrum. Bear et al. report that Ena/VASP proteins regulate cell motility by competing with capping proteins to control actin filament length and geometry at the leading edge of cells.