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Related Experiment Videos

Multiple fiber-optic dual-beam UV/Vis system with application to dissolution testing.

Jonas Johansson1, Michael Cauchi, Mats Sundgren

  • 1Analytical Development, AstraZeneca R&D Mölndal, S-431 83 Mölndal, Sweden. jonas.johansson@astrazeneca.com

Journal of Pharmaceutical and Biomedical Analysis
|June 14, 2002
PubMed
Summary

A new fiber-optic probing system enhances dissolution testing for pharmaceutical formulations. This advanced system accurately tracks drug release from various tablets, including complex multi-component ones.

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Area of Science:

  • Analytical Chemistry
  • Pharmaceutical Technology
  • Spectroscopy

Background:

  • Dissolution testing is crucial for evaluating solid pharmaceutical formulations.
  • Existing methods may lack the sensitivity or multi-component analysis capabilities required for complex drug products.

Purpose of the Study:

  • To develop and validate a novel fiber-optic probing system for enhanced dissolution testing.
  • To enable real-time, multi-component analysis of drug release from solid dosage forms.

Main Methods:

  • Construction of a system utilizing an imaging spectrometer and a cooled CCD detector.
  • Development of 12 fiber-optic probes with a unique dual-path reflection geometry.
  • Implementation of a deuterium lamp for UV light source and custom software for data analysis.

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Main Results:

  • The system successfully monitored drug release from prednisone tablets over 3 hours.
  • An extended-release tablet's linear dissolution profile was accurately tracked over 7 hours.
  • Separate dissolution profiles for two active components in a combination tablet were successfully obtained within 60 minutes.

Conclusions:

  • The developed fiber-optic probing system provides a sensitive and versatile platform for dissolution testing.
  • The system demonstrates robust capabilities for analyzing both simple and complex pharmaceutical formulations.
  • Future work will focus on expanding the multi-component analysis features.