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Updated: Aug 19, 2026
Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
Published on: June 14, 2017
[Value of the protein profile in the diagnosis of infectious endocarditis when hemolysis is present]
I de Lacroix-Szmania1, P Hausfater, R Dorent
1Service de médecine interne, centre hospitalier intercommunal de Créteil, 40, avenue de Verdun, 94010 Créteil, France. isabelle.delacroix@chicreteil.fr
Purpose:
Haptoglobin (H) and orosomucoid (O) are acute phase proteins that increase in a parallel manner. When hemolysis and inflammation are both present, study of the O-H couple on the protein profile may reveal an unknown hemolysis.
Methods:
To determine if hemolysis is more frequent during infectious endocarditis than during septicemia without valvulopathy or during valvulopathy without septicemia. Study of three groups of patients: 26 patients with infectious endocarditis, 13 patients with septicemia and 36 patients with valvulopathy without septicemia. Studied parameters were the O-H couple, hemoglobin and rate of O.
Results:
Hemolysis is clear in patients with endocarditis. The difference O-H is significantly more important during endocarditis than during septicemia without valvulopathy (P < 0.001) and during valvulopathy without sepsis (P < 0.001).
Conclusion:
Study of the O-H couple may be useful for the diagnosis of endocarditis showing a difficult-to-diagnose hemolysis.
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