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Updated: Jan 24, 2026

Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis
Published on: August 9, 2024
[Function of clara cells in lung remodeling]
Yasuo Morimoto1, Kazuhiro Yatera
1Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Abstract:
Clara cells localized in the bronchiole are thought to play a key role in lung remodeling. Clara cell secretory protein (CCSP), which is specifically produced by Clara cells, inhibits pro-inflammatory cytokines and chemotaxis of fibroblasts, and acts as phospholopase A2 inhibitors, and may also inhibit inflammation and fibrosis in the lung. This could be a biomarker of interstitial pneumonitis. Proliferation of Clara cells and neuroendocrine cells at airway epithelial injury may act as progenitor cells during the repair process.
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