Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Data on the action spectrum for ultraviolet carcinogenesis.

R G Freeman

    Journal of the National Cancer Institute
    |November 1, 1975
    PubMed
    Summary

    UV radiation at 300-320 nm wavelengths induced skin tumors in mice, similar to its redness-causing effects. Shorter wavelengths (290 nm) or lower doses did not cause tumors, indicating a specific UV range for skin cancer development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Report of Section Committee on Bacteriology of Milk in its Sanitary Relations.

    Public health papers and reports·2009
    Same author

    Submicrometer metallic barcodes.

    Science (New York, N.Y.)·2001
    Same author

    Ionic liquids based on FeCl(3) and FeCl(2). Raman scattering and ab initio calculations.

    Inorganic chemistry·2001
    Same author

    Wrinkling due to mid-dermal elastolysis: two cases and literature review.

    Journal of cutaneous medicine and surgery·2000
    Same author

    Self-Assembled Metal Colloid Monolayers: An Approach to SERS Substrates.

    Science (New York, N.Y.)·1995
    Same author

    A comparison of the efficacy and safety of Jessner's solution and 35% trichloroacetic acid vs 5% fluorouracil in the treatment of widespread facial actinic keratoses.

    Archives of dermatology·1995

    Area of Science:

    • Dermatology
    • Oncology
    • Photobiology

    Background:

    • Ultraviolet (UV) radiation is a known carcinogen.
    • Understanding the specific wavelengths responsible for UV-induced skin cancer is crucial for prevention and treatment.

    Purpose of the Study:

    • To determine the long wavelength limit of UV-induced skin carcinogenesis.
    • To compare the action spectrum of skin tumor development with that of erythema (redness).

    Main Methods:

    • Albino mice were exposed to monochromatic UV radiation at 300, 310, and 320 nm.
    • UV doses were administered proportionally to their erythemal effectiveness.
    • Tumor development and type were monitored in the exposed skin areas.

    Main Results:

    • Skin tumors developed at similar rates and times across all tested UV wavelengths (300-320 nm).
    • No tumors were observed at 290 nm or with low doses at 310 nm.
    • Tumors at 300 nm were exclusively squamous cell carcinomas; at 310 nm, both sarcomas and squamous cell carcinomas were observed.

    Conclusions:

    • The long wavelength limit for UV-induced skin carcinogenesis parallels that of erythema.
    • Specific UV wavelengths within the 300-320 nm range are effective in inducing skin tumors in mice.

    Related Experiment Videos