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[The natural history of colorectal cancer revisited]

Anne-Marie Bouvier1, Sylvain Manfredi, Catherine Lejeune

  • 1Registre Bourguignon des Cancers Digestifs, EPI INSERM 0106, Faculté de Médecine, BP 87900, 21079 Dijon Cedex. E-mail:.

Gastroenterologie Clinique Et Biologique
|June 18, 2002
PubMed
Abstract

No abstract available in PubMed .

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...