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Related Experiment Videos

Decoding of a motor command vector from distributed activity in superior colliculus.

Jeremy B Badler1, Edward L Keller

  • 1The Smith-Kettlewell Eye Research Institute, San Francisco, CA 94115, USA.

Biological Cybernetics
|June 19, 2002
PubMed
Summary

Vector summation (VS) and center-of-mass (CM) are decoding methods for neural networks. This study shows that dynamic neural networks in the superior colliculus (SC) can mimic CM results using VS, challenging previous interpretations of lesion studies.

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Area of Science:

  • Computational Neuroscience
  • Neural Systems
  • Motor Control

Background:

  • The superior colliculus (SC) generates saccadic eye movements via distributed neural activity.
  • Two proposed mechanisms for decoding motor commands from the SC are vector summation (VS) and center-of-mass (CM) computation.
  • Lesion studies in the SC have been interpreted as supporting the CM hypothesis.

Purpose of the Study:

  • To compare VS and CM decoding mechanisms in a dynamic neural network model of the SC.
  • To investigate whether intrinsic SC circuitry can explain observed saccadic error patterns after lesions.
  • To determine if CM computation is necessary to replicate physiological results.

Main Methods:

  • Simulated a discrete lesion in a recurrent neural network model of the SC.

Related Experiment Videos

  • Analyzed the effect of dynamic connections on the locus of distributed neural activity.
  • Compared the resulting saccadic error patterns with predictions from VS and CM hypotheses.

    • Main Results:

    • Dynamic connections in the model SC network caused a spatiotemporal shift in activity away from the lesion site.
    • This shift produced saccadic errors that mimicked patterns supporting the CM hypothesis.
    • Despite the CM-like errors, ensemble activity was decoded using VS in the model.

    Conclusions:

    • Focal SC lesions can produce saccadic error patterns consistent with CM computation, even when VS is the underlying decoding mechanism.
    • Dynamic modulation of neural activity by intrinsic SC circuitry can explain these findings.
    • An explicit CM computation is not required to reproduce the physiological results observed after SC lesions.