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[Intravenous 3-day Helicobacter pylori eradication therapy is highly effective in patients with bleeding peptic

F A Ruiz Gómez1, F J Sánchez Serrano, A Martínez Egea

  • 1Sección de Medicina Digestiva, Servicio de Medicina Interna, Hospital Universitario San Juan de Alicante, Alicante, Spain. rruiz_frago@gva.es

Gastroenterologia Y Hepatologia
|June 19, 2002
PubMed

Insights

A 3-day intravenous therapy effectively eradicated Helicobacter pylori in patients with bleeding peptic ulcers. This ultra-short course treatment showed high efficacy, comparable to oral regimens, with no adverse effects reported.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Pharmacology

Background:

  • Peptic ulcer bleeding is a significant clinical concern.
  • Helicobacter pylori infection is a primary cause of peptic ulcers.
  • Effective eradication of H. pylori is crucial for preventing recurrence and complications.

Purpose of the Study:

  • To assess the efficacy of a 3-day intravenous H. pylori eradication regimen.
  • To evaluate this therapy in patients presenting with bleeding peptic ulcers.
  • To compare outcomes with standard oral eradication treatments.

Main Methods:

  • A prospective study of 53 patients with bleeding peptic ulcers and H. pylori infection.
  • Intravenous administration of pantoprazole, metronidazole, and amoxicillin-clavulanic acid for 72 hours.
  • Efficacy confirmed by 13C-urea breath test at least 2 months post-treatment.

Main Results:

  • H. pylori eradication achieved in 87.5% of duodenal ulcer patients and 63.6% of gastric ulcer patients.
  • No adverse reactions or bleeding recurrence observed during the study.
  • High patient adherence and completion rates were noted.

Conclusions:

  • A 3-day intravenous H. pylori eradication therapy is highly effective for bleeding peptic ulcers.
  • This ultra-short course therapy demonstrates comparable efficacy to oral treatments.
  • The intravenous regimen offers advantages in managing adverse effects and improving treatment adherence.
Abstract

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