Related Experiment Videos
blaCTX-M-2 is located in an unusual class 1 integron (In35) which includes Orf513
Sonia M Arduino1, Paul H Roy, George A Jacoby
1Facultad de Medicina de la Universidad de Buenos Aires, Paraguay 2155 (1121)Capital Federal, Argentina. sarduino@aol.com
Antimicrobial Agents and Chemotherapy
|June 19, 2002
Abstract:
Examination of the bla(CTX-M-2) gene in plasmid pMAR-12 by sequencing and PCR analysis revealed that the bla gene and the surrounding DNA, which is closely related (99% homology) to the Kluyvera ascorbata chromosomal DNA that contains the bla(KLUA-1) gene, are located in a complex sul1-type integron, termed In35, that includes Orf513. It is possible that bla(CTX-M-2) was acquired by plasmid pMAR-12 through an uncharacterized recombinational event in which Orf513 could be involved.