[Fibrinogen metabolism and distribution in tourniquet-trauma]

The distribution and turn-over of 131J-labelled fibrinogen was studied in traumatized rats. Tourniquet-trauma resulted in a pronounced accumulation of labelled fibrinogen in the traumatized region. The accumulation was at the expense of all nontraumatized-tissue. In controls there was a parallel decline of total-body-activity and plasmaactivity. The T.B.A. of traumatized animals showed a similar disapprearance-rate, while there was a pronounced reduction of circulating labelled fibrinogen.