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Alpha-fetoprotein- and des-gamma-carboxy prothrombin-producing advanced gastric cancer
Eiji Ando1, Tetsuharu Oriishi, Atsushi Toyonaga
1Department of Medicine II, Kurume University School of Medicine, 67, Asahi-Machi, Kurume-shi, Fukuoka-ken, 830-0011, Japan. nyando@med-kurume-u.ac.jp
Abstract:
A case of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) producing gastric cancer with multiple liver metastasis is reported. The simultaneous presence of Borrmann I gastric cancer and IIa aggregating type gastric cancer was noted. Borrmann I gastric cancer was a poorly differentiated adenocarcinoma, while IIa aggregating type gastric cancer was a moderately differentiated adenocarcinoma. Plasma levels of AFP and DCP were 247,000 ng/ml and 320,000 mAU/ml, respectively. Immunohistochemical staining confirmed the production of these two proteins in Borrmann I gastric cancer.