Diffusion MRI findings in isolated intracranial angiitis

This paper reports an 8-year-old girl with proven primary (isolated) angiitis of the central nervous system. On diffusion MRI, multiple scattered lesions were noted in the internal capsulas, thalami, and in the left middle cerebellar pedincle. These were hyperintense on b=1000s/mm(2) (true diffusion) images. The apparent diffusion coefficient (ADC) values of these ranged between 0.40 and 0.52 x 10(-3)mm(2)/s, consistent with acute ischemic infarction (cytotoxic edema). The ADC values of a relatively old lesion in the left occipital region ranged between 1.65 and 1.82 x 10(-3)mm(2)/s, consistent with chronic infarction.