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Related Experiment Videos

Handling, genetic and housing effects on the mouse stress system, dopamine function, and behavior.

Jean-Louis Gariépy1, Ramona Marie Rodriguiz, Byron C Jones

  • 1Center for Developmental Science, University of North Carolina at Chapel Hill, 27599-8115, USA. jlgariepy@mindspring.com

Pharmacology, Biochemistry, and Behavior
|June 22, 2002
PubMed
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Early handling affects stress regulation differently in mice based on genetics and environment. Post-handling experiences like housing conditions and testing situations further modify these stress responses.

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Genetics

Background:

  • Early life experiences, including maternal care and handling, significantly influence adult stress regulation.
  • Genetic background plays a crucial role in modulating responses to early life stress.
  • Understanding these interactions is key to deciphering individual differences in stress-related disorders.

Purpose of the Study:

  • To investigate the interactive effects of early handling, housing conditions, and genetic factors on adult stress regulation in mice.
  • To examine how these factors influence behavioral and physiological stress responses.
  • To determine if the effects of early handling are consistent across different measures and testing paradigms.

Main Methods:

  • Utilized high-aggressive (NC900) and low-aggressive (NC100) mouse lines.

Related Experiment Videos

  • Applied early postpartum handling for three weeks.
  • Assessed adult stress responses using open field tests, dyadic encounters, and corticosterone (CORT) level measurements.
  • Manipulated housing conditions (isolation vs. group rearing) post-handling.

    • Main Results:

    • Handling reduced corticosterone (CORT) activation and stabilized activity in low-aggressive (NC100) mice, but not high-aggressive (NC900) mice.
    • Group rearing further reduced CORT in handled NC100 mice.
    • Handling increased D1 dopamine receptors in both lines, an effect amplified by group rearing in NC100 mice.
    • Behavioral differences emerged: NC100 mice froze less, while NC900 mice attacked more readily in dyadic encounters.

    Conclusions:

    • The impact of early handling on stress regulation is significantly modulated by genetic background.
    • Post-infancy experiences, such as housing, further influence the long-term effects of early stimulation.
    • Handling effects vary depending on the physiological system and the social or nonsocial context of assessment.