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Published on: March 29, 2017
Effects of Roxithromycin on the production of lipase and neutrophil chemotactic factor by Propionibacterium acnes
H Akamatsu1, T Tomita, T Horio
1Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan. akamatsu@fujita-hu.ac.jp
Background:
The macrolide antibiotic roxithromycin is effective against acne associated with inflammation, but the mechanism by which this is achieved has not been clarified.
Objective:
We studied the effects of roxithromycin on the production of lipase and neutrophil chemotactic factor by Propionibacterium acnes in vitro.
Results:
Roxithromycin significantly inhibited the production of lipase and neutrophil chemotactic factor by P. acnes at a concentration one eighth of the MIC, at which the growth curve of P. acnes is not affected.
Conclusion:
One mechanism of the effectiveness of roxithromycin in acne therapy is thought to be the inhibition of bacterial lipase and neutrophil chemotactic factor production by P. acnes.
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