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[Antibiotic combinations in Staphylococcus aureus infections: arguments against]
J Albanese1, A Bourgouin, C Martin
1Réanimation et centre de traumatologie, hôpital Nord, chemin des Bourrelly, 13915 Marseille, France.
Annales Francaises D'Anesthesie Et De Reanimation
|June 25, 2002
Abstract:
In a case of severe infection due to Staphylococcus aureus, generally accepted practice involves the use of a combination of antibiotics. This article examines the type and quality of the experimental and clinical data which has been collected in this context. Published findings suggest that the arguments in favour of combinations are usually theoretical, and that a demonstration of the superiority of combinations has never been made by comparative, randomised studies.