Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunoisolation techniques for islet cell transplantation.

Emmanuel C Opara1, William F Kendall

  • 1Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA. opara001@mc.duke.edu

Expert Opinion on Biological Therapy
|June 25, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scalable 3D Bioprinting of Human Islets in a Pancreatic Decellularized Extracellular Matrix-Enriched Bioink for Beta-Cell Replacement Therapy.

bioRxiv : the preprint server for biology·2025
Same author

Effect of controlled release of HGF on extracellular vesicle secretion by urine-derived stem cells.

Frontiers in bioengineering and biotechnology·2024
Same author

Corrigendum to 'Engineered multilayer ovarian tissue that secretes sex steroids and peptide hormones in response to gonadotropins' [Biomaterials 34/10 (2013) 2412-2420].

Biomaterials·2024
Same author

Neurobiological insights into lower urinary tract dysfunction: evaluating the role of brain-derived neurotrophic factor.

American journal of clinical and experimental urology·2023
Same author

Decellularized human pancreatic extracellular matrix-based physiomimetic microenvironment for human islet culture.

Acta biomaterialia·2023
Same author

A Simple Mathematical Model Demonstrates the Potential for Cell-Based Hormone Therapy to Address Dysregulation of the Hypothalamus-Pituitary-Ovary Axis in Females with Loss of Ovarian Function.

Annals of biomedical engineering·2023
Same journal

Biologic modulation of ineffective erythropoiesis in thalassemia: mechanisms, clinical practice, and future targets.

Expert opinion on biological therapy·2026
Same journal

TNF inhibitors for the long-term management of juvenile idiopathic arthritis associated uveitis: real-life data from the ITHACA cohort.

Expert opinion on biological therapy·2026
Same journal

Type 2 inflammation and biologics: a twenty-year journey.

Expert opinion on biological therapy·2026
Same journal

Current outlook on the use of biological agents to improve outcomes in adult secondary hemophagocytic lymphohistiocytosis.

Expert opinion on biological therapy·2026
Same journal

Addressing challenges in disease management of childhood-onset systemic lupus erythematosus: the role of biologics, with primary focus on rituximab and belimumab.

Expert opinion on biological therapy·2026
Same journal

Biological drugs for the treatment of children with atopic dermatitis.

Expert opinion on biological therapy·2026
See all related articles

Islet cell transplantation shows promise for treating Type 1 diabetes complications. Microencapsulation techniques aim to overcome challenges like cell shortage and immune rejection, paving the way for routine treatment.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Endocrinology

Background:

  • Diabetes mellitus causes severe complications like retinopathy, nephropathy, neuropathy, and cardiovascular disease.
  • Islet cell transplantation offers a potential solution to prevent or reverse these diabetes-related complications.
  • Current limitations include a shortage of donor pancreases and the necessity for immunosuppressive drugs.

Purpose of the Study:

  • To explore islet cell transplantation as a viable treatment for Type 1 diabetes.
  • To address the obstacles hindering routine islet cell transplantation.
  • To investigate immunoisolation strategies for enhanced transplant success.

Main Methods:

  • Review of recent studies on islet cell transplantation.

Related Experiment Videos

  • Analysis of immunoisolation procedures, specifically microencapsulation.
  • Evaluation of potential for reduced immunosuppression.

    • Main Results:

    • Islet cell transplantation is a promising alternative to whole pancreas transplantation.
    • Microencapsulation techniques show potential for immunoisolating islet cells.
    • These methods could overcome donor scarcity and reduce reliance on immunosuppressants.

    Conclusions:

    • Microencapsulation of islet cells is a key strategy to overcome transplantation barriers.
    • This approach holds significant potential for widespread clinical application in treating Type 1 diabetes.
    • The ultimate goal is an unlimited supply of transplantable cells with minimal immunosuppression.