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Biological drugs for the treatment of children with atopic dermatitis

Mattia Giovannini1,2, Leticia de Las Vecillas3, Maria De Filippo4,5

  • 1Allergy Unit, Meyer Children's Hospital IRCCS, Florence, Italy.

Expert Opinion on Biological Therapy
|June 22, 2026
PubMed

Insights

Targeted therapies are improving pediatric atopic dermatitis (AD) management. Key challenges include long-term safety data, biomarker strategies, and equitable access to these advanced treatments for children.

Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Atopic dermatitis (AD) is a chronic inflammatory skin condition impacting children's quality of life.
  • Advances in understanding AD immunopathogenesis have spurred targeted therapeutic development.

Purpose of the Study:

  • To review available and emerging targeted therapies for pediatric AD.
  • To connect mechanistic insights with current and future biologics and JAK inhibitors.
  • To highlight limitations in pediatric evidence, real-world data, and treatment selection.

Main Methods:

  • Literature review of PubMed and clinical trial databases.
  • Focus on studies evaluating targeted systemic treatments in pediatric AD patients.

Main Results:

  • Targeted therapies are transforming pediatric AD management.
  • Improved disease control and quality of life are observed with these treatments.

Conclusions:

  • Targeted therapies offer significant benefits for pediatric AD.
  • Long-term safety, biomarker-guided strategies, and access remain critical challenges.
Abstract

Keywords:
Biologicsatopic dermatitismonoclonal antibodiespediatricsprecision medicinesmall molecules

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